Article ID Journal Published Year Pages File Type
10838110 Pharmacology Biochemistry and Behavior 2012 9 Pages PDF
Abstract
► We investigated atypical antipsychotics and their interaction with P-gp at the BBB. ► Inhibitory potency, pharmacokinetics and pharmacodynamics were investigated. ► Amisulpride, N-desmethylclozapine, olanzapine and quetiapine are substrates of P-gp. ► Ranking of drugs for inhibitory potency is reflected in their pharmacodynamics. ► Pharmacodynamic effects were best correlated to brain levels not accessible in humans.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
In vitro P-glycoprotein efflux inhibition by atypical antipsychotics is in vivo nicely reflected by pharmacodynamic but less by pharmacokinetic changes
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