| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10838129 | Pharmacology Biochemistry and Behavior | 2011 | 7 Pages |
Abstract
⺠Blockade of either 5-HT3- or NK1-receptors reduce emesis caused by an agonist of each receptor. ⺠Relative to each antagonist tested alone, their combination is more potent against each emetogen. ⺠Combined doses of each agonist induce greater number of vomits relative to each emetogen alone. ⺠Emetic cross-talk occurs between serotonergic 5-HT3 and tachykininergic NK1 receptors. ⺠Synergistic antiemetic effects occur when combination antagonists are used against each emetogen.
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Authors
Nissar A. Darmani, Seetha Chebolu, Barry Amos, Tursun Alkam,