| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10838137 | Pharmacology Biochemistry and Behavior | 2011 | 5 Pages |
Abstract
⺠The behavioral effects of the D3 agonist, pramipexole (PPX) were tested in rats. ⺠PPX caused dose- and time-dependent biphasic changes in locomotor activity (LA). ⺠PPX-hyperactivity (min 50-90) was D2-dependent; PPX-hypoactivity (min 0-30) was not. ⺠PPX disrupted PPI at times corresponding to both PPX-hyper- and -hypoactivity. ⺠Disparate mechanisms regulate PPC effects on LA vs. PPI.
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Authors
Wei-li Chang, Michelle R. Breier, Alex Yang, Neal R. Swerdlow,