| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10838142 | Pharmacology Biochemistry and Behavior | 2011 | 5 Pages |
Abstract
⺠Naltrexone is an inverse agonist and 6β-naltrexol is a neutral opioid antagonist. ⺠Naltrexone and 6β-naltrexol precipitate opioid withdrawal. ⺠Naltrexone acts additively with 6β-naltrexol to precipitate withdrawal. ⺠6β-naltrexol dose-dependently decreases or increases the potency of naltrexone. ⺠Constitutive opioid receptor activity may not increase with opioid dependence.
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Authors
Dipesh M. Navani, Sunil Sirohi, Priyanka A. Madia, Byron C. Yoburn,