Article ID Journal Published Year Pages File Type
10838145 Pharmacology Biochemistry and Behavior 2011 8 Pages PDF
Abstract
► P rats self-infused 200-800 pmol and Wistar rats only self-infused 800 pmol cocaine. ► P rats received more cocaine infusions compared to Wistar rats during acquisition. ► P rats infused more cocaine than Wistar rats during reinstatement. ► Compared to Wistar rats, the AcbSh of P rats was more sensitive to cocaine. ► The AcbSh of P rats may have become sensitized to the reinforcing effects of cocaine.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Alcohol-preferring (P) rats are more sensitive than Wistar rats to the reinforcing effects of cocaine self-administered directly into the nucleus accumbens shell
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