| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10838149 | Pharmacology Biochemistry and Behavior | 2011 | 8 Pages |
Abstract
⺠The enzyme fatty acid amide hydrolase (FAAH) metabolizes the endocannabinoid anandamide. ⺠FAAH inhibition or genetic deletion, reduced collagen-induced arthritis and hyperalgesia. ⺠Anti-inflammatory & anti-hyperalgesic FAAH (-/-) phenotype was mediated by non-neuronal cells. ⺠Endocannabinoid catabolic enzymes are a target for anti-inflammatory analgesic therapeutics.
Keywords
N-oleoylethanolamide2-arachidonoylglycerolFAAHCB2transient receptor potential cation channel, subfamily V, member 1URB597CB12-AGPEAN-palmitoylethanolamideNSAIDTHCAEATRPV1OEAΔ9-Tetrahydrocannabinolcollagen-induced arthritisanandamideendocannabinoidfatty acid amide hydrolase (FAAH)Fatty acid amide hydrolaseChronic inflammationnonsteroidal anti-inflammatory drugInflammatory painRIMCIAcannabinoid receptor type 1cannabinoid receptor type 2
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Authors
Steven G. Kinsey, Pattipati S. Naidu, Benjamin F. Cravatt, David T. Dudley, Aron H. Lichtman,