| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10838165 | Pharmacology Biochemistry and Behavior | 2011 | 9 Pages |
Abstract
⺠We examine aged African Green monkeys for signs of Parkinson's disease. ⺠We utilize a sensitive behavioral measure for correlating dopamine function with signs of parkinsonism. ⺠Aged monkeys had signs similar to MPTP-exposed adult monkeys. ⺠Treatment with dopamine agonists does not restore normal function in aged monkeys as it often fails to do in older patients with Parkinson's disease. ⺠We show a greater loss of dopamine in putamen than in caudate, a pattern that is more similar to human Parkinson's disease than the pattern seen after MPTP exposure.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
P.J. Hurley, J.D. Elsworth, M.C. Whittaker, R.H. Roth, D.E. Jr.,