Article ID Journal Published Year Pages File Type
10838166 Pharmacology Biochemistry and Behavior 2011 9 Pages PDF
Abstract
► Hesperidin showed depressant and antinociceptive effects only by the i.p. route. ► Hesperidin actions in vivo are mediated by an opioid mechanism of action. ► Hesperetin did not show any central nervous system effects in vivo in mice. ► Hesperetin binds to mu-opioid receptor with low-affinity. ► Hesperetin inhibited inward GIRK1/2 currents expressed in Xenopus oocytes.
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Hesperidin induces antinociceptive effect in mice and its aglicone, hesperetin, binds to μ-opioid receptor and inhibits GIRK1/2 currents
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