| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10838168 | Pharmacology Biochemistry and Behavior | 2011 | 7 Pages |
Abstract
⺠Fish oil has shown cognitive/mental benefits, but coadjutant antioxidants are apparently necessary based on a hormesis principle. ⺠Anxiety behavior has been related to highly oxidative-sensitive regions in mammal brains. ⺠Fish oil augmented oxidative injuries in the anterior forebrain of rats but apparently showed anxiolytic effects. ⺠Salmonid carotenoid astaxanthin increased antioxidant capacity in plasma and inhibited oxidative injury in rat brains. ⺠It is still unclear if astaxanthin exerts its antioxidant effects in situ or indirectly by preserving reduced glutathione in plasma.
Keywords
MnSODTBARSNBTTEACFRAPDTNBGPXASTACATCuZnSODTrolox-equivalent antioxidant capacityTEPBHTFRCEPAMDA5,5′-dithio-bis(2-nitrobenzoic acid)ROSnitroblue tetrazoliumAstaxanthinAntioxidantEicosapentaenoic aciddocosahexaenoic acidAnxietyOmega-3Omega-3 polyunsaturated fatty acidselevated plus mazeDHAFish oilSODSuperoxide dismutasemanganese-dependent superoxide dismutasemalondialdehydeBrainthiobarbituric acid reactive substancesbutylated hydroxytoluenebody weightCatalaseCarotenoidglutathione reductaseglutathione peroxidaseReactive oxygen species
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Authors
Rita Mattei, Tatiana G. Polotow, Cristina V. Vardaris, Beatriz A. Guerra, José Roberto Leite, Rosemari Otton, Marcelo P. Barros,