Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10838189 | Pharmacology Biochemistry and Behavior | 2011 | 10 Pages |
Abstract
⺠Acute administration of amphetamine (5.0 mg/kg) or quinpirole (0.12 mg/kg) disrupted prepulse inhibition of acoustic startle response. ⺠Repeated administration of amphetamine (5.0 mg/kg) or quinpirole (0.12 mg/kg) lost its disruption. ⺠An escalating dosing regimen with amphetamine (1.0-5.0 mg/kg) produced a persistent disruption over time. ⺠Acute and repeated treatment of phencyclidine (0.50-2.0 mg/kg) or MK-801 (0.025-0.10 mg/kg) produced a stable and persistent disruption of PPI.
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Authors
Ming Li, Wei He, Jing Chen,