Exposure to nicotine during periadolescence or early adulthood alters aversive and physiological effects induced by ethanol

► This study assessed the impact of adolescent nicotine on alcohol-induced aversions. ► This was then related to nicotine's effects on other alcohol-induced phenotypes. ► Nicotine reduced the aversiveness of alcohol, regardless of age when preexposed. ► Nicotine reduced alcohol-induced hypothermia, regardless of age when preexposed. ► Nicotine-induced changes in alcohol's effects could increase its reinforcing value.