| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10838213 | Pharmacology Biochemistry and Behavior | 2011 | 9 Pages |
Abstract
âºAC927 alone has no significant effects on striatal serotonin levels, striatal serotonin transporter expression, or body temperature. âºAC927 attenuates methamphetamine-induced hyperthermia at ambient, room temperature. âºAC927 attenuates methamphetamine-induced neurotoxicity as measured as reductions in striatal serotonin levels and serotonin transporter expression. âºThere is a significant correlation between body temperature and striatal serotonin levels. âºAt high ambient temperature, AC927 attenuates methamphetamine-induced lethality, but does not reduce body temperature to saline-like levels.
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Authors
Michael J. Seminerio, Nidhi Kaushal, Jamaluddin Shaikh, Jason D. Huber, Andrew Coop, Rae R. Matsumoto,