Article ID Journal Published Year Pages File Type
10838229 Pharmacology Biochemistry and Behavior 2011 10 Pages PDF
Abstract
► The decreased level of autophage was involved in D-galactose-induced murine senescence and the adjustment of autophagy was associated with NF-kB activation. ► The damaged oxidoreductase activities associated with the disorder of autophagy regulation in hippocampal neurons of D-galactose-induced senescent mice were founded in this study. ► Silibinin promoted the cellular oxidoreductase activities, upregulated the level of autophagy in hippocampal neurons, and reversed the impaired spatial recognition memory and escaping reaction acquisition of senescent mice via inhibiting NF-kB activation and ROS production.
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