Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10838229 | Pharmacology Biochemistry and Behavior | 2011 | 10 Pages |
Abstract
⺠The decreased level of autophage was involved in D-galactose-induced murine senescence and the adjustment of autophagy was associated with NF-kB activation. ⺠The damaged oxidoreductase activities associated with the disorder of autophagy regulation in hippocampal neurons of D-galactose-induced senescent mice were founded in this study. ⺠Silibinin promoted the cellular oxidoreductase activities, upregulated the level of autophagy in hippocampal neurons, and reversed the impaired spatial recognition memory and escaping reaction acquisition of senescent mice via inhibiting NF-kB activation and ROS production.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Qiong Wang, Libo Zou, Weiwei Liu, Wenbo Hao, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejima,