| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10838254 | Pharmacology Biochemistry and Behavior | 2011 | 7 Pages |
Abstract
⺠Metabolism impairment and abnormal PKC activity are involved in bipolar disorder. ⺠TMX is a PKC inhibitor and interacts with mitochondrial respiratory chain. ⺠In an animal model of mania TMX decreases locomotor activity. ⺠TMX changes energetic metabolism parameters in parallel with behavioral changes. ⺠Inhibitors of PKC may act as a possible target for new medications to BD.
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Authors
Morgana Moretti, Samira S. Valvassori, Amanda V. Steckert, Natalia Rochi, Joana Benedet, Giselli Scaini, Flávio Kapczinski, Emilio L. Streck, Alexandra I. Zugno, João Quevedo,