| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10838260 | Pharmacology Biochemistry and Behavior | 2011 | 6 Pages |
Abstract
âºFentanyl-trazodone-paracetamol display a synergistic interaction on antinociception. ⺠The combined treatment don't affect exploratory activity and motor coordination. ⺠Multimodal analgesia by the triple combination leads to a higher benefit/risk profile. ⺠Naloxone abrogates the enhanced antinociceptive effects of the three-drug treatment. ⺠The opioid endogenous system may be involved in the synergistic drug-drug interaction.
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Authors
VÃctor Fernández-Dueñas, Raquel Poveda, Alejandro Fernández, SÃlvia Sánchez, Eulà lia Planas, Francisco Ciruela,