| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10838262 | Pharmacology Biochemistry and Behavior | 2011 | 8 Pages |
Abstract
⺠Intracerebellar microinfusion of cAMP or cpt-cAMP dose dependently attenuated ethanol-induced ataxia. ⺠Sustained antagonism of ethanol-induced ataxia followed a single microinfusion of cAMP or cpt-cAMP that lasted > 25 h or > 31 h post-microinfusion. ⺠Consistent failure of ethanol to produce ataxia in animals microinfused cAMP or cpt-cAMP was not due to the development of tolerance to ethanol. ⺠The critical role of cAMP suggests an involvement of AC/cAMP/PKA signaling in ethanol-induced ataxia and its co-modulation by adenosine A1 and GABAA.
Keywords
CPT-cAMPN6-cyclohexyladenosinecyclic adenosine mono phosphateintracerebellarICBERKpKaaCSFcAMPcerebellar ataxiaMRIanalysis of varianceANOVAMagnetic resonance imagingPositron emission tomographydorso-ventralanterior–posteriorartificial cerebrospinal fluidmillimolarCHAMedio-lateralPETprotein kinase Aextracellular signal-regulated kinases
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Authors
M. Saeed Dar,