| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10838263 | Pharmacology Biochemistry and Behavior | 2011 | 7 Pages |
Abstract
⺠Phosphodiesterase 4 (PDE4) is a target for developing novel antidepressants. ⺠PDE4B and PDE4D levels were elevated in cingulate cortical tissue from individuals with depression. ⺠Selective and potent PDE4 inhibitors enhanced sexual pleasure-seeking activity in male mice. ⺠PDE4 may contribute to the sexual pleasure-seeking deficits seen in depressed patients. ⺠Inhibiting PDE4 may restore these deficits.
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Authors
Peixiong Yuan, Tyson Tragon, Menghang Xia, Christopher A. LeClair, Amanda P. Skoumbourdis, Wei Zheng, Craig J. Thomas, Ruili Huang, Christopher P. Austin, Guang Chen, Xavier Guitart,