| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10838282 | Pharmacology Biochemistry and Behavior | 2011 | 9 Pages |
Abstract
⺠Rats display sensitization of locomotor behavior with daily cocaine administration. ⺠Rats also show behavioral sensitization by increasing their intake of hypertonic saline solution (i.e. salt appetite) in response to daily DOCA (a mineralocorticoid agonist) treatment. ⺠Animals that are sensitized to one treatment (e.g., DOCA without access to saline) will evidence cross-sensitization to the second treatment (i.e., cocaine) and vice versa. ⺠The results suggest that the reciprocal cross-sensitization between the two behavior-inducing treatments may be related to activation of common neural substrates.
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Authors
Martin J. Acerbo, Alan Kim Johnson,