Article ID Journal Published Year Pages File Type
10838302 Pharmacology Biochemistry and Behavior 2011 7 Pages PDF
Abstract
►Combined escitalopram and WAY-100635 treatment decrease avoidance response behaviour in rats. ►The combined treatment decrease basal extracellular levels of dopamine in the nucleus accumbens. ►No change in extracellular levels of dopamine in the striatum. ►The combined treatment has an antipsychotic-like effect with mesolimbic selectivity. ►Pretreatment with the 5-HT2C receptor, SB242084, prevented these effects.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Combination of escitalopram and a 5-HT1A receptor antagonist selectively decreases the extracellular levels of dopamine in the nucleus accumbens relative to striatum through 5-HT2C receptor stimulation; suggestive of antipsychotic potential
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