| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10838323 | Pharmacology Biochemistry and Behavior | 2011 | 9 Pages |
Abstract
âºRisperidone and fluoxetine were evaluated in the BTBR T+tf/J (BTBR) mouse model of autism and C57BL/6J (B6) mice by using the three-chambered social approach test and elevated plus maze to determine effects on sociability and anxiety. âºFluoxetine increased sociability, defined as time spent with a stranger mouse, in the BTBR mice without affecting anxiety-like behavior in the elevated plus maze. âºFluoxetine did not significantly change either behavior in the B6 mice. âºRisperidone did not affect sociability or anxiety-like behaviors and had a sedative-like effect at higher doses.
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Authors
Kathryn K. Chadman,