Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10838535 | Pharmacology Biochemistry and Behavior | 2005 | 5 Pages |
Abstract
Inhibition of nitric oxide synthase (NOS) antagonizes nitrous oxide (N2O)-induced antinociception in mice. This study was conducted to compare brain NOS activity in high responding C57BL/6 mice, low responding DBA/2 mice and S5 mice selectively bred for low responsiveness to N2O. Exposure to 70% N2O suppressed acetic acid-induced abdominal constrictions in C57BL/6 mice but not DBA/2 or S5 mice. N2O exposure also elevated NOS activity in brains of C57BL/6 mice but not DBA/2 or S5 mice. The absence of these effects in DBA/2 or S5 mice is further support for the hypothesis that nitric oxide (NO) may play a critical role in N2O-induced antinociception in mice.
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Authors
Elisabeth Day Henry, Yusuke Ohgami, Shuang Li, Eunhee Chung, Raymond M. Quock,