Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10838660 | Pharmacology Biochemistry and Behavior | 2005 | 7 Pages |
Abstract
The antinociceptive effect of (+)-matrine was examined in mice by writhing, tail-pressure and hot-plate tests. (+)-Matrine (5, 10 and 20 mg/kg s.c.) produced antinociception in a dose-dependent manner. In hot-plate test, the antinociception produced by (+)-matrine (10 mg/kg s.c.) was attenuated by muscarinic receptor antagonists atropine (5 mg/kg i.p.) and pirenzepine (0.1 μg/mouse i.c.v.) and acetylcholine depletor hemicholinium-3 (HC-3) (1 μg/mouse i.c.v.), but not by opioid receptor antagonist naloxone (2 mg/kg i.p.), dopamine D2 receptor agonist (â)-quinpirole (0.1 mg/kg i.p.) or catecholamine depletor reserpine (2.5 mg/kg i.p.). Radioligand binding assay demonstrated that (+)-matrine had no affinity for μ-, κ- or δ-opioid receptors in a wide concentration range (1Ã10â11-1Ã10â3 M). The results suggest that (+)-matrine exerts its antinociceptive effect through multiple mechanism(s) such as increasing cholinergic activation in the CNS rather than acting on opioid receptors directly.
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Authors
Lin-Lin Yin, Xing-Zu Zhu,