| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10838682 | Pharmacology Biochemistry and Behavior | 2005 | 6 Pages |
Abstract
These data show that MCL0042 has unique properties of both the MC4 receptor antagonist and serotonin transporter inhibitor, and produces anxiolytic and antidepressant activity in rats. Moreover, blockade of both the MC4 receptor and serotonin reuptake sites might represent a useful approach in the treatment of anxiety and depression.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Shigeyuki Chaki, Yuichi Oshida, Shin-ichi Ogawa, Takeo Funakoshi, Toshiharu Shimazaki, Taketoshi Okubo, Atsuro Nakazato, Shigeru Okuyama,