| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10838821 | Pharmacology Biochemistry and Behavior | 2005 | 18 Pages |
Abstract
ED50's for the occurrence of side-effects were compared to ED50's in behavioural pain tests. Fentanyl had a strong analgesic potency and, compared to other opioids, an acceptable side-effect profiling at analgesic ED50's. Also consistent was the ceiling effect of buprenorphine implying an increased safety margin for side-effects, but a decreased analgesic efficacy. Differences between opioids as observed in this study can have important indications for their use in acute as well as in the onset of chronic treatments.
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Authors
Theo F. Meert, Hilde A. Vermeirsch,