Article ID Journal Published Year Pages File Type
10843198 Protein Expression and Purification 2013 7 Pages PDF
Abstract
► A single-chain Fv can be successful constructed from a humanized BC-1 immunoglobulin. ► The scFv (HuBC-1) is more stable the its murine counterpart. ► The HuBC-1 scFv retains full binding function by ELISA, BIACore analyses and flow cytometry. ► The HuBC-1 scFv is stable and localizes to tumours in an animal model.
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Authors
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