Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10843198 | Protein Expression and Purification | 2013 | 7 Pages |
Abstract
⺠A single-chain Fv can be successful constructed from a humanized BC-1 immunoglobulin. ⺠The scFv (HuBC-1) is more stable the its murine counterpart. ⺠The HuBC-1 scFv retains full binding function by ELISA, BIACore analyses and flow cytometry. ⺠The HuBC-1 scFv is stable and localizes to tumours in an animal model.
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Authors
Nor Adzimah Johdi, Ruth Harman, Irene Sanjuan, Christina Kousparou, Nigel Courtenay-Luck, Mahendra P. Deonarain,