Article ID Journal Published Year Pages File Type
10845280 Regulatory Peptides 2011 5 Pages PDF
Abstract
► We model hemorrhagic stroke in vitro on olfactory cortex slices of hypertensive rats. ► We use electrophysiologic recordings to analyze basal glutamatergic and GABABergic synaptic transmission. ► Autoblood blocks synaptic transmission in neurons of brain slices. ► l-carnosine pretreatment of slices may rescue the mechanisms of synaptic plasticity being inhibited by autoblood exposure. ► l-carnosine attenuates edema in olfactory cortex by improving function of glutamate receptors.
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