Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10845302 | Regulatory Peptides | 2005 | 10 Pages |
Abstract
The stretch of adult papillary muscle elicits a chain of autocrine/paracrine events in which the Na+/H+ exchanger (NHE-1) activation is the central step. This activation is induced by a sequential angiotensin II-endothelin (Ang II-ET) release and results in an increase in intracellular Na+ (Na+i) without significant changes in intracellular pH. The increase in Na+i negatively shifts the reverse potential of the Na+/Ca2+ exchanger (NCX) thus inducing cell Ca2+ influx that augments myocardial contractility. This increase in force represents the mechanical counterpart of the autocrine/paracrine mechanism triggered by stretch and has been called the slow force response (SFR) to stretch.
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Authors
Horacio E. Cingolani, Néstor G. Pérez, Ernesto A. Aiello, MarÃa C. Camilión de Hurtado,