| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10845671 | Seminars in Cancer Biology | 2009 | 6 Pages |
Abstract
Since its discovery as the first human tumor virus, Epstein-Barr virus (EBV) has been implicated in the development of a wide range of B-cell lymphoproliferative disorders, the first being Burkitt lymphoma. However, the exact mechanism by which EBV promotes oncogenesis is still matter of discussion. A role in EBV-mediated transformation has been proposed for a novel described class of small non-coding RNAs, the microRNAs (miRNAs). EBV encodes viral miRNAs, through which it may interfere with the physiological regulation exterted by cellular miRNAs. In addition, EBV-coded proteins may also disturb the well-orchestrated mechanisms of regulation of cellular function. In this review, we will focus on the role of EBV in malignant transformation of Burkitt lymphoma, with a particular insight in the interplay between the virus and cellular miRNAs.
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Authors
Giulia De Falco, Giuseppina Antonicelli, Anna Onnis, Stefano Lazzi, Cristiana Bellan, Lorenzo Leoncini,