Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10845679 | Seminars in Cancer Biology | 2005 | 10 Pages |
Abstract
Neoplasms progress to cancer through a process of natural selection. The rate of evolution, and thus progression is determined by three parameters: mutation rate, population size of the evolving neoplastic cells, and intensity of selection or rate of clonal expansion. All three parameters are reviewed in the context of Barrett's esophagus, a pre-malignant neoplasm. Although Barrett's esophagus is an ideal model for the study of neoplastic clonal evolution, similar studies may be carried out in a wide variety of human neoplasms. Evolutionary analyses provide insights for clinical management, including rates of progression to cancer and emergence of resistance to interventions.
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Authors
Carlo C. Maley, Brian J. Reid,