Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10845809 | Seminars in Cancer Biology | 2005 | 9 Pages |
Abstract
Extravasation has been described as a rate-limiting step in the process of hematogeneous metastasis formation. Thereby, transendothelial migration of tumor cells consists of a complex series of events involving multiple cell-cell and cell-matrix interactions. 3D-extravasation assays are valuable tools for the identification of genes, which are the key players at switchboards of the intracellular signaling pathways. In consequence, the combination of 3D-modeling and whole genome expression analysis lead to unravel molecular parameters which descripe distinct clinical phenotypes of cancer and therefore, work as prognosticators, predictors of therapy and new therapy targets.
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Authors
Burkhard Brandt, Christoph Heyder, Eva Gloria-Maercker, Wolfgang Hatzmann, Antje Rötger, Dirk Kemming, Kurt S. Zänker, Frank Entschladen, Thomas Dittmar,