Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10845812 | Seminars in Cancer Biology | 2005 | 8 Pages |
Abstract
Biomedical researchers have become increasingly aware of the limitations of time-honored conventional 2D tissue cell cultures where most tissue cell studies have been carried out. They are now searching for 3D cell culture systems, something between a petri dish and a mouse. It has become apparent that 3D cell culture offers a more realistic micro- and local-environment where the functional properties of cells can be observed and manipulated that is not possible in animals. A newly designer self-assembling peptide scaffolds may provide an ideally alternative system. The important implications of 3D tissue cell cultures for basic cell biology, tumor biology, high-content drug screening, and regenerative medicine and beyond could be profound.
Keywords
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Authors
Shuguang Zhang, Fabrizio Gelain, Xiaojun Zhao,