Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10845852 | Seminars in Cancer Biology | 2005 | 9 Pages |
Abstract
Tumor-stromal interactions induce expression of matrix metalloproteinases and serine proteases and, as shown recently, the cysteine protease cathepsin B. We speculate that such interactions upregulate the transcription factor Ets1, resulting in increased cathepsin B expression. This would be consistent with the observed concomitant upregulation of matrix metalloproteinases and serine proteases as well as with the ability of extracellular matrices and their binding partners to alter cathepsin B expression and secretion. Using a confocal assay to analyze the contribution of tumor-stromal interactions to proteolysis, we have been able to confirm enhanced degradation of extracellular matrices by all three classes of proteases.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Bonnie F. Sloane, Shiqing Yan, Izabela Podgorski, Bruce E. Linebaugh, Michael L. Cher, Jianxin Mai, Dora Cavallo-Medved, Mansoureh Sameni, Julie Dosescu, Kamiar Moin,