| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10847654 | Steroids | 2015 | 5 Pages |
Abstract
Intraperitoneally injected sitosterol and 7β-hydroxysitosterol differently influence cholesterol metabolism in plasma and liver. We conclude that the polar 7β-hydroxysitosterol compound can pass the blood brain barrier with higher efficacy than its substrate, sitosterol. Though present in higher amounts in the brain, both, sitosterol and 7β-hydroxysitosterol do not influence cholesterol metabolism in the brain as proven by our surrogate markers.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Hans-Frieder Schött, Constanze Husche, Silvia Friedrichs, Charlotte M. Miller, Florence O. McCarthy, Ulrich Laufs, Jogchum Plat, Oliver Weingärtner, Dieter Lütjohann,