Vitamin D receptor signaling mechanisms: Integrated actions of a well-defined transcription factor

Article ID	Journal	Published Year	Pages	File Type
10847704	Steroids	2013	10 Pages	PDF

Abstract

âº Vitamin D signaling primarily implies the molecular actions of the VDR. âº We present the actions of VDR from different molecular perspectives. âº We position vitamin D signaling in relation to other intracellular signaling systems.

Keywords

Sp100 VDR FXR HDM VDRE Retinoid X receptor arachidonate 5-lipoxygenase CDKN1A hMT IGFBP Trefoil factor 1 COA DR3 DIO1 COR HDAC LXR CCNC ChIP-Seq ALOX5 CyP LBD DBD TSS RAR RXR Cyclin C TFF1 direct repeat spaced by 3 nucleotides KLK3 1α,25(OH)2D3 1α,25-dihydroxyvitamin D3 25(OH)D3 25-hydroxyvitamin D3 cAMP farnesoid X receptor micro RNA chromatin immunoprecipitation Gene regulation DNA-Binding Domain ligand-binding domain transcription start site Cytochrome P450 Response elements vitamin D response element cyclin-dependent kinase inhibitor 1A MiRNA Co-repressor Co-activator Histone acetyltransferase histone deacetylase histone demethylase Histone Methyltransferase Vitamin D insulin-like growth factor binding protein CHiP liver X receptor Chromatin HAT Androgen Receptor Estrogen receptor Retinoic acid receptor Mineralocorticoid receptor thyroid hormone receptor Vitamin D receptor Progesterone receptor glucocorticoid receptor Nuclear receptor