Article ID Journal Published Year Pages File Type
10847705 Steroids 2013 10 Pages PDF
Abstract
► Estrogen carcinogenesis involves both ER dependent and independent mechanisms. ► Promotion of cell proliferation increases errors during DNA replication. ► Oxidative metabolites of estrogens cause direct DNA damage and mutation. ► Unbalanced metabolism of estrogens increases breast cancer risk.
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Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
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Estrogen receptor-dependent and independent mechanisms of breast cancer carcinogenesis
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