Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10847750 | Steroids | 2005 | 7 Pages |
Abstract
Starting from D-seco derivatives of 5-androstene 1-3, the D-homo lactones, 4 and 5, were synthesized. By the Oppenauer oxidation and/or by dehydration of 4 and 5 with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) or 2,3,5,6-tetrachloro-1,4-benzoquinone (chloranil), the corresponding D-lactones 6-12 were obtained. The structures of 6 and 10 were unambiguously proved by the appropriate X-ray structural analysis. Anti-aromatase assay showed that tested compounds possess inhibition potency, however, two to four times smaller (IC50 from 0.2 to 0.7 μM, respectively) in comparison to aminoglutethimide (AG).
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Authors
Katarina M. Penov GaÅ¡i, Srdjan Z. StojanoviÄ, Marija N. SakaÄ, Mirjana Popsavin, Suzana JovanoviÄ Å anta, Slobodanka M. StankoviÄ, Olivera R. KlisuriÄ, NebojÅ¡a AndriÄ, Radmila KovaÄeviÄ,