| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10847842 | Steroids | 2005 | 7 Pages |
Abstract
Trimethylsilylcyanide addition to different carbonyl moieties, i.e. saturated ketones, an enone and an aldehyde, at the steroid side-chain, was studied in the presence of a convenient catalyst. Depending on the nature of the carbonyl group, different outcomes were noticed. Saturated 20-keto pregnanes yielded epimerically pure silylated cyanohydrins, being the absolute configuration unambiguously established by X-ray crystallographic analysis.
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Authors
M. Manuel Cruz Silva, Lourdes C.R. Andrade, José A. Paixão, M. José de Almeida, M. Luisa Sá e Melo,