Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10847857 | Steroids | 2005 | 11 Pages |
Abstract
Linear oligoesters based on etienic acid (3β-hydroxyandrost-5-ene-17β-carboxylic acid) containing four steroid units were prepared using a 2 + 2 synthetic strategy in a successful synthesis of 3β-{[3β-({3β-[(3β-hydroxyandrost-5-ene-17β-carbonyl)oxy]androst-5-ene-17β-carbonyl}oxy)androst-5-ene-17β-carbonyl]oxy}androst-5-ene-17β-carboxylic acid. The main problems with deprotection were overcome by using orthogonal groups as O-nitrates and 2-(trimethylsilyl)ethyl ethers.
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Authors
Pavel DraÅ¡ar, MiloÅ¡ BudÄÅ¡Ãnský, Miroslav Reschel, VladimÃr Pouzar, Ivan Äerný,