| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10848081 | Steroids | 2012 | 8 Pages |
Abstract
⺠Steroids oxygenated at the 3, 17 and 19 carbons potently inhibit steroid biosynthesis. ⺠These steroids act through an interaction with the CRAC motif of the TSPO. ⺠Steroids oxygenated at the 3, 17 and either the 4, 7 or 11 carbons inhibit steroidogenesis at a post-TSPO step. ⺠Androstenetriol derivatives oxygenated at multiple positions are non-toxic.
Keywords
cytochrome P450 11A1PBRAndrostenetriol22R-HydroxycholesterolCRACdbcAMP22R-HCTSPOCYP11A13-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromidecAMPMTTCyclic adenosine monophosphateSteroidogenesischolesterol recognition/interaction amino acid consensusdibutyryl cyclic adenosine monophosphatecholesterolperipheral benzodiazepine receptor
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Authors
Andrew Midzak, Georges Rammouz, Vassilios Papadopoulos,