| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10848099 | Steroids | 2012 | 15 Pages |
Abstract
⺠Androstane(ene)s were examined in urine from neonates with 21-hydroxylase deficiency. ⺠The major 3β-hydroxy-5-enes in disease are identical to those in unaffected neonates. ⺠GC-MS and GC-MS/MS characterization of androstanes andandrostenediones is presented. ⺠New metabolites contain 6,11,16-oxo and 2α/β,6α,11β,16 and 18-hydroxy groups. ⺠Multiple metabolites of androstenedione indicate dominance of the classical pathway.
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Authors
Sofia Christakoudi, David A. Cowan, Norman F. Taylor,