Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10848110 | Steroids | 2005 | 7 Pages |
Abstract
Four new C-21 steroidal glycoside, stemucronatosides D (1), E (2), F (3), and G (4) were isolated from the roots of Stephanotis mucronata. Their structures were determined on the basis of chemical evidence and extensive spectroscopic methods including one-dimensional and two-dimensional NMR. These isolated compounds were assayed for their immunological activities in vitro against concanavalin A (Con A)- and lipopolysaccharide (LPS)-induced proliferation of mice splenocytes. Compounds 1, 2, and 4 showed immunosuppressive activities in a dose-dependent manner, while compound 3 showed immunomodulating activities.
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Authors
Yiping Ye, Hongxiang Sun, Xiaoyu Li, Fengyang Chen, Feng Qin, Yuanjian Pan,