Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10848118 | Steroids | 2005 | 7 Pages |
Abstract
A repeated silica gel column chromatography followed by HPLC purification on the methanol extract of marine soft coral Sinularia dissecta, resulted in the isolation of fifteen polyhydroxylated steroids (1-15), involving six new C-18 functionalized steroids, 3β-acetoxy-1α,11α-dihydroxygorgost-5-en-18-oic acid (1), gorgost-5-en-1α,3β,11α,18-tetrol (2), 18-acetoxy-1α,3β,11α-trihydroxygorgost-5-ene (3), 24(S)-3β-acetoxy-1α, 11α-dihydroxyergost-5-en-18-oic acid (4), 24(S)-ergost-5-en-1α,3β,11α,18-tetrol (5), and dissectolide (6). The structures of the new compounds were determined on the basis of extensive spectroscopic data (IR, MS, 1H and 13C NMR, HMQC, HMBC, and NOESY) analysis. Compound 6 was found as an unusual sterol bearing a lactone functionality.
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Authors
Pengfei Jin, Zhiwei Deng, Yuehu Pei, Hongzheng Fu, Jun Li, Leen Van Ofwegen, Peter Proksch, Wenhan Lin,