Functional promoter polymorphisms of the receptor for advanced glycation end products in children and adolescents with type 1 diabetes

RAGE promoter polymorphisms are associated with increases in RAGE expression. A case-control association study was conducted involving a Euro-Brazilian population of children and adolescents with type 1 diabetes (n = 90) and healthy controls (n = 105), which were matched by sex and age. Genotyping by PCR-RFLP the −429T>C (rs1800625), −374T>A (rs1800624), and 63 bp deletion/insertion (−407 to −345 bp) showed no significant differences (P > 0.05) between the groups.