Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10962151 | Tuberculosis | 2014 | 7 Pages |
Abstract
IL-22 has been suggested to play an important role in immune response against Mycobacterium tuberculosis infection. However, the exact role of IL-22 in human tuberculosis (TB) infection remains unclear and the regulatory mechanism of IL-22 response in human TB is unknown. In this study, we observed that successful anti-tuberculosis treatment induced an enhanced and sustained M. tuberculosis antigen-specific IL-22 response, correlated with the decrease of the frequencies of CD19+CD5+CD1d+ regulatory B cells. We also found that depletion of CD19+ B cells significantly enhanced M. tuberculosis antigen-specific IL-22 production by peripheral blood mononuclear cells. More importantly, we observed that purified CD19+ B cells, and more efficiently, CD19+CD5+CD1d+ regulatory B cells, suppressed IL-22 production. In summary, we showed here for the first time that effective anti-tuberculosis treatment restores M. tuberculosis antigen-specific IL-22 response through a novel mechanism by reducing the frequencies of CD19+CD5+CD1d+ regulatory B cells in human TB.
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Authors
Mingxia Zhang, Gucheng Zeng, Qianting Yang, Jieyun Zhang, Xiuyun Zhu, Qi Chen, Pichaimuthu Suthakaran, Ying Zhang, Qunyi Deng, Haiying Liu, Boping Zhou, Xinchun Chen,