Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10962171 | Tuberculosis | 2012 | 36 Pages |
Abstract
Data gathered from preclinical in vitro and in vivo assays during personal visits to laboratories and an electronic survey of methodologies sent to investigators is reported. Comments, opinions, experiences as well as final recommendations from those currently engaged in such preclinical studies for TB drug testing are being presented. Certain in vitro assays and mouse efficacy models were re-evaluated in the laboratory as head-to-head experiments and a summary is provided on the results obtained. It is our hope that this information will be a valuable resource for investigators in the field to move forward in an efficient way and that key variables of assays are included to ensure accuracy of results which can then be used for designing human clinical trials. This document then concludes with remaining questions and critical gaps that are in need of further validation and experimentation.
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Authors
Scott G. Franzblau, Mary Ann DeGroote, Sang Hyun Cho, Koen Andries, Eric Nuermberger, Ian M. Orme, Khisimuzi Mdluli, Iñigo Angulo-Barturen, Thomas Dick, Veronique Dartois, Anne J. Lenaerts,