Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10962193 | Tuberculosis | 2015 | 5 Pages |
Abstract
MTB MICs were found to be consistently lower for MXF than for OFX among isolates with the same gyrA mutation (e.g. Ala90Val). The majority of MTB isolates containing mutations at Asp94Ala, Asn/Tyr, Gly and His in gyrA were associated with a moderate level of resistance to MXF (MIC = 2.5 μg/ml), although 3 isolates with the mutations Asp94Asn/Tyr/Gly were associated with a high level of resistance to both fluoroquinolones (MXF MICs = 5.0-8.0 μg/ml, OFX MICs = â¥10.0 μg/ml).
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Authors
Priti Kambli, Kanchan Ajbani, Meeta Sadani, Chaitali Nikam, Anjali Shetty, Zarir Udwadia, Timothy C. Rodwell, Antonino Catanzaro, Camilla Rodrigues,