Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10962271 | Tuberculosis | 2011 | 7 Pages |
Abstract
IL-22 was readily detected in fluid from both disease sites. These IL-22 levels exceeded matching peripheral blood levels. Further, IL-22 levels in pericardial fluid correlated positively with MMP-9, an enzyme known to degrade the pulmonary extracellular matrix. We propose that our findings support a role for IL-22 in TB-induced pathology or the resulting repair process.
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Authors
Kerryn Matthews, Katalin A. Wilkinson, Barbara Kalsdorf, Teri Roberts, Andreas Diacon, Gerhard Walzl, Janine Wolske, Mpiko Ntsekhe, Faisal Syed, James Russell, Bongani M. Mayosi, Rodney Dawson, Keertan Dheda, Robert J. Wilkinson, Willem A. Hanekom,