| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10992 | Biomaterials | 2005 | 7 Pages |
A histological study was performed of bone biopsies from 16 patients (17 biopsies) treated with open wedge high tibial osteotomies for medial knee osteoarthritis. The open wedge osteotomies were filled with a wedge of osteoconductive beta tricalcium phosphate (β-TCP) ceramic bone replacement. At the time of removal of the fixation material, core biopsies of the area where the β-TCP was located were taken at different follow-up periods (6–25 months). β-TCP resorption, bone ingrowth and bone remodelling were studied. We hypothesized that the incorporation and remodelling process occurs similarly as in animals.Histology showed a good resorption of the β-TCP with complete incorporation and remodelling into new bone. The different phases as described in animal studies were found. A correlation was found between histological findings and radiological assessment.In conclusion, β-TCP appeared to be a bone replacement material with optimal biocompatibility, resorption characteristics and bone conduction properties for the clinical use.
