| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10999766 | Biomaterials | 2018 | 11 Pages |
Abstract
Surface engineering of pancreatic islets by jagged-1 (JAG-1) and poly(ethylene glycol) (PEG). (A) Immunoisolation of pancreatic islet surface by a double-layer of PEG. Although PEGylation can protect the islets from infiltration of immune cells and reduce host-cell interactions, the cytokines produced by immune cells can still potentially diffuse through this barrier. (B) Immobilization of JAG-1 as an immunomodulatory agent on the PEGylated islets surface can induce an immunomodulatory milieu thought induction of Tregs, upregulation of anti-inflammatory cytokines, and downregulation of inflammatory cytokines around the islets to enable efficient islet immunoprotection.188
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Authors
Zhila Izadi, Ensiyeh Hajizadeh-Saffar, Jamshid Hadjati, Mahdi Habibi-Anbouhi, Mohammad Hossein Ghanian, Hamid Sadeghi-Abandansari, Mohammad Kazemi Ashtiani, Zakieh Samsonchi, Mohammad Raoufi, Maedeh Moazenchi, Mahmoud Izadi,