Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
11007711 | Acta Histochemica | 2018 | 13 Pages |
Abstract
This review aims to summarize the changes of the NOS/NO system which occur in the lungs, gills, kidney, heart, and myotomal muscle of air breathing fish of the genus Protopterus, i.e. P. dolloi and P. annectens, in relation to the switch from freshwater to aestivation, and vice-versa. The modifications of NOS and its partners Akt and Hsp-90, and HIF-1α, detected by immunohistochemical and molecular biology methods, are discussed together with the apoptosis rate, evaluated by TUNEL. We hypothesize that these molecular components are key elements of the stress-induced signal transduction/integration networks which allow the lungï¬sh to overcome the dramatic environmental challenges experienced at the beginning, during, and at the end of the dry season.
Keywords
GBMhypoxia inducible factor αP-eNOSphospho-eNOsHSP-90GFRHIF-1αnNOSeNOSiNOSNOSCOXCX43neuronal NOSinducible NOSROSfreshwatercyclooxygenaseAktEnvironmental stressendothelial NOSApoptosisapoptosis repressor with caspase recruitment domainAestivationArcGlomerular filtration rateNitric oxidenitric oxide synthaseHeat shock protein 90connexin 43radical oxygen species
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Authors
Bruno Tota, Daniela Amelio, Maria Carmela Cerra, Filippo Garofalo,